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Facile synthesis and micellization of biodegradable poly(decamethylene succinate)-graft-poly(ethylene glycol)

Authors

  • Guixiang Zhu,

    1. SINOPEC Beijing Research Institute of Chemical Industry, Beijing 100013, China
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  • Ying Wang,

    1. MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China
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  • Weipu Zhu,

    Corresponding author
    1. MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China
    • Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China
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  • Kui Zhu,

    1. MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China
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  • Xiaoyan Xu,

    Corresponding author
    1. MOE Key Laboratory of Advanced Civil Engineering Materials, School of Materials Science and Engineering, Tongji University, Shanghai 201804, People's Republic of China
    • Ministry of Education Key Laboratory of Advanced Civil Engineering Materials, School of Materials Science and Engineering, Tongji University, Shanghai 201804, China
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  • Zhiquan Shen

    1. MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, People's Republic of China
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Abstract

In this article, we report the facile one-pot synthesis of poly(decamethylene succinate) (PDS) with multiple hydroxyl groups by direct polycondensation with malic acid (MA) as the functional monomer and dysprosium triflate as the chemoselective catalyst at 80°C. The secondary hydroxyl groups of malic units were inactive during the polycondensation process. The density of hydroxyl groups of the copolymer could be well-controlled by the molar ratio of succinic acid and MA in the feed. These hydroxylated PDSs were grafted by poly(ethylene glycol) (PEG) through a simple esterification reaction; this resulted in amphiphilic PDS-g-PEG copolymers, which could undergo micellization in aqueous media to form nanosized aggregates with diverse morphologies and diameters. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013.

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