Encapsulation and release of cladribine from chitosan nanoparticles

Authors

  • Rachel E. Domaratzki,

    1. Chemical Engineering Program, Department of Process Engineering and Applied Sciences, Dalhousie University, Halifax, Nova Scotia, Canada B3J 2X4
    Search for more papers by this author
  • Amyl Ghanem

    Corresponding author
    1. Chemical Engineering Program, Department of Process Engineering and Applied Sciences, Dalhousie University, Halifax, Nova Scotia, Canada B3J 2X4
    • Chemical Engineering Program, Department of Process Engineering and Applied Sciences, Dalhousie University, Halifax, Nova Scotia, Canada B3J 2X4
    Search for more papers by this author

Abstract

This study shows the potential of chitosan (CH) nanoparticles as both an oral and IV drug delivery system using the anticancer drug cladribine as a model drug. Smooth, spherical nanoparticles were prepared by the ionotropic gelation of CH with sodium tripolyphosphate. Nanoparticle size depended on degree of hydration, drug loading, and crosslinking conditions, with the smallest nanoparticles in the size range of 212 ± 51 nm. Cladribine was entrapped in the CH matrix with an entrapment efficiency of up to 62%, depending on the initial loading. The release of cladribine followed a near-Fickian diffusion rate over the first several hours and then reached a plateau. A second release phase began after 30–40 h of incubation in the release medium, and proceeded until ∼100 h. Loaded CH nanoparticles that were crosslinked with genipin showed a delayed release profile, with only 40% of loaded drug being released after 100 h. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

Ancillary