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Fabrication and surface characterization of electrosprayed poly(L-lactide) microspheres

Authors

  • Changmin Hu,

    1. School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai 200030, the People's Republic of China
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  • Jingwen Zhao,

    1. School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai 200030, the People's Republic of China
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  • Wenguo Cui

    Corresponding author
    1. School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai 200030, the People's Republic of China
    • School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai 200030, the People's Republic of China or
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Abstract

Electrospraying is a one-step technique for fabricating polymeric microspheres/nanospheres, and the surface characterization of polymeric microspheres fabricated under high voltage is different from an emulsion method. In this study, biodegradable poly(l-lactide) (PLLA) microspheres were successfully fabricated by electrospraying, and electrospraying parameters were used to investigate the size and ζ potential of the electrosprayed PLLA microspheres. The results demonstrate that electrospraying was a one-step method for fabricating monodispersed PLLA microspheres with a size of 1.92 ± 0.35 μm and that the enrichment of methyl groups on the surface of the microspheres contributed to the strong hydrophobicity of electrosprayed PLLA microspheres. Of all the electrospraying parameters investigated, the size and ζ potential of the PLLA microspheres increased with increasing solution concentration and flow rate and decreased with increasing injection voltage and collecting distance. The results provide a theoretical basis for preparing electrosprayed polymeric microspheres as drug carriers. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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