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Synthesis of biomimetic hyperbranched zwitterionic polymers as targeting drug delivery carriers

Authors

  • Xiaohong Wang,

    1. Key Laboratory of Advanced Textile Materials and Manufacturing Technology (Ministry of Education), Zhejiang Sci-Tech University, Hangzhou 310018, China
    2. Department of Materials Engineering, College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China
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  • Xinke Sun,

    1. Key Laboratory of Advanced Textile Materials and Manufacturing Technology (Ministry of Education), Zhejiang Sci-Tech University, Hangzhou 310018, China
    2. Department of Materials Engineering, College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China
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  • Guohua Jiang,

    Corresponding author
    1. Key Laboratory of Advanced Textile Materials and Manufacturing Technology (Ministry of Education), Zhejiang Sci-Tech University, Hangzhou 310018, China
    2. Department of Materials Engineering, College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China
    • Key Laboratory of Advanced Textile Materials and Manufacturing Technology (Ministry of Education), Zhejiang Sci-Tech University, Hangzhou 310018, China
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  • Rijing Wang,

    1. Key Laboratory of Advanced Textile Materials and Manufacturing Technology (Ministry of Education), Zhejiang Sci-Tech University, Hangzhou 310018, China
    2. Department of Materials Engineering, College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China
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  • Ruanbing Hu,

    1. Key Laboratory of Advanced Textile Materials and Manufacturing Technology (Ministry of Education), Zhejiang Sci-Tech University, Hangzhou 310018, China
    2. Department of Materials Engineering, College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China
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  • Xiaoguang Xi,

    1. Key Laboratory of Advanced Textile Materials and Manufacturing Technology (Ministry of Education), Zhejiang Sci-Tech University, Hangzhou 310018, China
    2. Department of Materials Engineering, College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China
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  • Yang Zhou,

    1. Department of Materials Engineering, College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China
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  • Sheng Wang,

    1. Key Laboratory of Advanced Textile Materials and Manufacturing Technology (Ministry of Education), Zhejiang Sci-Tech University, Hangzhou 310018, China
    2. Department of Materials Engineering, College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China
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  • Tao Wang

    1. Key Laboratory of Advanced Textile Materials and Manufacturing Technology (Ministry of Education), Zhejiang Sci-Tech University, Hangzhou 310018, China
    2. Department of Materials Engineering, College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China
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  • These authors contributed equally to this research work

Abstract

Novel biomimetic hyperbranched copolymers that synthesized by polymerization of zwitterionic monomer (CBB) on the surface of a hyperbranched poly(3-ethyl-3-(hydroxymethyl)oxetane) (HBPO) core and used as a drug delivery carrier have been investigated by analysis of protein-adsorption-resistance, cytotoxicity and cell type-specific targeting properties. The as-synthesized biomimetic hyperbranched copolymers showed low toxicity, favorable protein resistant properties and were ultrastable in 100% fetal bovine serum. Folic acid and rodiamin-B were conjugated to the surface of synthesized micelles to endow it with target drug delivery and fluorescence activity, respectively. Intracellular uptake and in vitro cytotoxicity of HBPO-poly(carboxybetaine) micelles were investigated. Doxorubicin was used as a model drug for Hela cells during the experiment. All results show that the biomimetic hyperbranched copolymer is a candidate carrier for target drug delivery. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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