Preparation and properties of poly(benzyl glutamate)–poloxamer–poly(benzyl glutamate) and poly(glutamic acid)–poloxamer–poly(glutamic acid) triblock polymers

Authors

  • Xi Ting Wang,

    1. Department of Pharmaceutical and Biological Engineering, College of Chemical Engineering, Sichuan University, Chengdu 610065, China
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  • Jing Wang,

    1. Department of Pharmaceutical and Biological Engineering, College of Chemical Engineering, Sichuan University, Chengdu 610065, China
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  • Hai Long Sun,

    1. Department of Pharmaceutical and Biological Engineering, College of Chemical Engineering, Sichuan University, Chengdu 610065, China
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  • Xiang Yu Du,

    1. Department of Pharmaceutical and Biological Engineering, College of Chemical Engineering, Sichuan University, Chengdu 610065, China
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  • Li Fang Ma

    Corresponding author
    1. Department of Pharmaceutical and Biological Engineering, College of Chemical Engineering, Sichuan University, Chengdu 610065, China
    • Department of Pharmaceutical and Biological Engineering, College of Chemical Engineering, Sichuan University, Chengdu 610065, China
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Abstract

The novel block copolymer poly(benzyl glutamate) (PBLG)–polomamer–PBLG were synthesized from glutamic acid and poloxamer in six steps with three different molecular weights, and another new block copolymer, poly(glutamic acid) (PGA)–poloxamer–PGA, was obtained by the benzyl deprotection of PBLG–poloxamer–PBLG. The obtained compounds were characterized by IR spectroscopy, gel permeation chromatography, and 1H-NMR. The in vitro biological degradation and water absorption of PBLG showed that a greater proportion of PBLG in the copolymer led to a slower degradation and weaker water absorption, so the speed of degradation and water absorption could be adjusted through adjustment of the ratio of poloxamer. Both PBLG–poloxamer–PBLG and PGA–poloxamer–PGA exhibited lower cytotoxicity and good biocompatibility in the methyl thiazolyl tetrazolium (MTT) assay. The results show that both block polymers are promising as drug-carrier materials. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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