Poly (D,L) lactic acid blending with vitamin E increases polymer hemocompatibility: An hydrophilic effect

Authors

  • Filippo Renò,

    Corresponding author
    1. Health Sciences Department, Research Centre for Biocompatibility and Tissue Engineering, University of Eastern Piedmont “A. Avogadro”, Via Solaroli 17, 28100 Novara, Italy
    • Health Sciences Department, Research Centre for Biocompatibility and Tissue Engineering, University of Eastern Piedmont “A. Avogadro”, Via Solaroli 17, 28100 Novara, Italy
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  • Geo Paul,

    1. Department of Sciences and Technological Innovation, University of Eastern Piedmont “A. Avogadro”, Viale T. Michel 11, 15121 Alessandria, Italy
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  • Manuela Rizzi,

    1. Health Sciences Department, Research Centre for Biocompatibility and Tissue Engineering, University of Eastern Piedmont “A. Avogadro”, Via Solaroli 17, 28100 Novara, Italy
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  • Giorgio Gatti,

    1. Department of Sciences and Technological Innovation, University of Eastern Piedmont “A. Avogadro”, Viale T. Michel 11, 15121 Alessandria, Italy
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  • Leonardo Marchese

    1. Department of Sciences and Technological Innovation, University of Eastern Piedmont “A. Avogadro”, Viale T. Michel 11, 15121 Alessandria, Italy
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Abstract

Biocompatible and resorbable polylactic acid (PLA) derived polymers are used for clinical applications. Antioxidant vitamin E (Vit.E) and vitamin E acetate (Vit.E Ac), a Vit.E commercial analog, were added to PLA during films preparation. Wettability, protein adsorption analysis, platelet adhesion and whole blood coagulation experiments highlighted that Vit.E incorporation improved PLA hemocompatibility. NMR analysis showed that Vit.E and Vit.E Ac blending differentially altered PLA polymer organization with Vit.E leading to the formation of microcavities, as observed by SEM analysis, while reducing surface hydrophobicity. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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