Environmental pH-responsive fluorescent PEG-polyurethane for potential optical imaging

Authors

  • Hong Yu Yang,

    1. Engineering Research Center of Synthetic Resin and Special Fiber, Ministry of Education, Changchun University of Technology, Changchun 130012, China
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  • Xiu Mei Zhang,

    1. Department of Radiology, The First Hospital of Jilin University, Changchun 130021, China
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  • Li Jie Duan,

    1. Engineering Research Center of Synthetic Resin and Special Fiber, Ministry of Education, Changchun University of Technology, Changchun 130012, China
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  • Ming Yao Zhang,

    1. Engineering Research Center of Synthetic Resin and Special Fiber, Ministry of Education, Changchun University of Technology, Changchun 130012, China
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  • Guang Hui Gao,

    Corresponding author
    1. Engineering Research Center of Synthetic Resin and Special Fiber, Ministry of Education, Changchun University of Technology, Changchun 130012, China
    • Engineering Research Center of Synthetic Resin and Special Fiber, Ministry of Education, Changchun University of Technology, Changchun 130012, China
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  • Hui Xuan Zhang

    1. Engineering Research Center of Synthetic Resin and Special Fiber, Ministry of Education, Changchun University of Technology, Changchun 130012, China
    2. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130012, China
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Abstract

A series of environmental pH-responsive block copolymers PEG-polyurethane with tertiary amine groups in the main chain and free carboxyl groups in the side chain were synthesized, including poly(ethylene glycol) (PEG), 1,4-bis (hydroxyethyl) piperazine, 1,6-diisocyanato hexamethylene, and 2,2-dimethylolpropionic acid. The chemical structure, molecular weight, and pH-dependent capacity of pH-responsive PEG-polyurethane were examined by 1H-NMR, FTIR, gel permeation chromatography (GPC), and an acid-base titration. Moreover, the fluorescent dye fluorescein isothiocyanate was conjugated with PEG-polyurethane by the similar polymerization method and the obtained polymer was measured by ultraviolet visible spectroscopy (UV-vis) and fluorescent spectroscopy. The results indicated that the pH-responsive PEG-polyurethane showed a pH-buffering phenomenon and fluorescent imaging in a range of pH values. As a result, we demonstrated its potential application for optical imaging; however, it is believed that more applications in the areas of biomedicine will be possible owing to its free carboxyl acid terminal residues in the stimuli-responsive polymer. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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