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Preparation and characterization of cyhalothrin-loaded poly(2-hydroxyethyl methacrylate)-co-polylactide (PHEMA-co-PLA) ultrafine particles

Authors

  • Tengfei Fan,

    1. College of Science, China Agricultural University, Beijing 100193, People's Republic of China
    2. National Center for Nanoscience and Technology, Laboratory of Nanobiomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, Beijing 100190, People's Republic of China
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  • Xuemin Wu,

    1. College of Science, China Agricultural University, Beijing 100193, People's Republic of China
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  • Yan Wu

    Corresponding author
    1. National Center for Nanoscience and Technology, Laboratory of Nanobiomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, Beijing 100190, People's Republic of China
    • National Center for Nanoscience and Technology, Laboratory of Nanobiomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, Beijing 100190, People's Republic of China
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Abstract

Poly(2-hydroxyethyl methacrylate)-co-polylactide (PHEMA-co-PLA) and its corresponding cyhalothrin-loaded ultrafine particles were successfully synthesized and prepared, respectively. The chemical structures of the copolymers have been confirmed by Fourier transform infrared spectroscopy (FTIR), 1H-nuclear magnetic resonance (1H-NMR), 13C-nuclear magnetic resonance (13C-NMR), and thermogravimetric analysis (TGA). Furthermore, the particle size, the cyhalothrin loading content (LC), and the cyhalothrin release behavior were investigated. PHEMA-co-PLA proved to be a good material for the preparation of ultrafine particles for lipophilic pesticide delivery. The developed cyhalothrin-loaded PHEMA-co-PLA ultrafine particles showed good dispersity in water and sustained release behavior. In addition, it is easy to be prepared by both nanoprecipitation method and emulsion/solvent evaporation method. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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