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Suprarmolecular hydrogels based on low-molecular-weight poly(ethylene glycol) and α-cyclodextrin

Authors

  • Cheng-Gong Guo,

    1. College of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049, People's Republic of China
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  • Liang Wang,

    1. College of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049, People's Republic of China
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  • Ya-Kun Li,

    1. College of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049, People's Republic of China
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  • Cai-Qi Wang

    Corresponding author
    1. College of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049, People's Republic of China
    • College of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049, People's Republic of China
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Abstract

In previous studies, crystalline precipitates, not stable hydrogels, were obtained when low-molecular-weight (MW) poly(ethylene glycol) (PEG; weight-average MW = 400–5000) was used to interact with α-cyclodextrin (α-CD). In this study, the gelation ability of low-MW PEG (number-average MW = 2000, PEG-2000) and α-CD was systematically investigated through the variation in the concentration of PEG-2000 in water (CPEG-2000) and the feeding molar ratio of the PEG repeat unit to α-CD (R). The results show that a stable supramolecular hydrogel could be constructed when CPEG-2000 was kept at 40 mg/mL and R was 6.3. The inclusion complexation between α-CD and PEG-2000 and the effect of CPEG-2000 and R on the stability of the hydrogels were characterized by differential scanning calorimetry, X-ray diffraction, scanning electron microscopy, and rheology measurements. The resulting PEG-2000-based hydrogels retained the basic characteristics of supramolecular physical hydrogels, especially the property of shear thinning. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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