Layer-by-layer assembly of poly(allylamine hydrochloride)/polyurethane and its loading and release behavior for methylene orange

Authors

  • Wenjiao Jian,

    1. Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education, College of Chemistry and Chemical Engineering, Xinjiang University, Xinjiang 830046, People's Republic of China
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  • Shimei Xu,

    1. Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education, College of Chemistry and Chemical Engineering, Xinjiang University, Xinjiang 830046, People's Republic of China
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  • Jide Wang,

    1. Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education, College of Chemistry and Chemical Engineering, Xinjiang University, Xinjiang 830046, People's Republic of China
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  • Shun Feng

    Corresponding author
    1. Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education, College of Chemistry and Chemical Engineering, Xinjiang University, Xinjiang 830046, People's Republic of China
    • Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education, College of Chemistry and Chemical Engineering, Xinjiang University, Xinjiang 830046, People's Republic of China
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Abstract

Here, layer-by-layer technique was used for sequential adsorption of oppositely charged polymer poly(allylamine hydrochloride) (PAH) and polyurethane (PU) through electrostatic interaction. 10 and 10.5 bilayer films were prepared separately, methylene orange (MO) was used as a model drug to evaluate the potential ability of this multilayer film used in drug delivery system. Experimental results showed the ability of loading and release of MO from the film was significantly influenced by pH and salt concentration, the loading rate of MO was faster and larger with increasing salt concentration or decreasing pH of MO solution, the release rate of MO was faster at higher salt concentration or in alkali solution. The result also indicated that the film had a good reversibility of loading and release. PAH/PU film could be a promising drug delivery system because of its biocompatibility, biodegradation and above properties. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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