Alginate hydrogel sphere improves the alkali and heat resistances of isothiazolinones with long-term antibacterial activity

Authors

  • Dong Ma,

    Corresponding author
    • Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou, People's Republic of China
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    • D. Ma and X. Cai contributed equally to this article.

  • Xiang Cai,

    Corresponding author
    1. Department of Chemistry, Jinan University, Guangzhou, People's Republic of China
    • Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou, People's Republic of China
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    • D. Ma and X. Cai contributed equally to this article.

  • Qianming Lin,

    1. Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou, People's Republic of China
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  • Jinglin Zhang,

    1. Department of Chemistry, Jinan University, Guangzhou, People's Republic of China
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  • Wenjie Mai,

    1. Department of Physics and Siyuan Laboratory, Jinan University, Guangzhou, People's Republic of China
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  • Shaozao Tan,

    1. Department of Chemistry, Jinan University, Guangzhou, People's Republic of China
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  • Wei Xue,

    1. Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou, People's Republic of China
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  • Ting Wu

    Corresponding author
    • R&D Center, Guangzhou Liby Enterprise Group Company, Guangzhou, People's Republic of China
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Correspondence to: D. Ma (E-mail: asd-0077@163.com) or T. Wu (E-mail: angelwu2006@163.com)

ABSTRACT

To improve the alkali and heat resistances of Cl+Me-isothiazolinone (MCI/MI), a calcium alginate (CA) hydrogel sphere was used as the carrier for MCI/MI, and an MCI/MI/CA hydrogel sphere was prepared. Then, the release properties, alkali-resistance and heat-resistance properties, long-term antibacterial performance, and cytotoxicity of this novel hydrogel sphere were investigated. The results show that the CA hydrogel sphere released MCI/MI in a sustained manner with long-term antibacterial activity. Moreover, the CA hydrogel sphere improved the alkali and heat resistances of the MCI/MI. More importantly, this hydrogel sphere showed a slight cytotoxicity, which suggested that the MCI/MI/CA hydrogel sphere would be an easily added antibacterial hydrogel sphere for a wide range of products. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 1554–1561, 2013

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