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Glutaraldehyde-crosslinked chitosan/hydroxyapatite bone repair scaffold and its application as drug carrier for icariin

Authors

  • Yan Li,

    1. Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education, Shanghai, China
    2. School of Materials Science and Engineering, Tongji University, Shanghai, China
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  • Taotao Liu,

    1. School of Materials Science and Engineering, Tongji University, Shanghai, China
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  • Jun Zheng,

    1. Shanghai University of Traditional Chinese Medicine, Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai, China
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  • Xiaoyan Xu

    Corresponding author
    1. School of Materials Science and Engineering, Tongji University, Shanghai, China
    • Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education, Shanghai, China
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Correspondence to: X. Xu (E-mail: kadxxy@tongji.edu.cn)

ABSTRACT

Chitosan/hydroxyapatite (CS/HA) bone repair scaffolds crosslinked by glutaraldehyde (GA) were prepared. Characterization of morphology, structure, mechanical property, and porosity of scaffolds were evaluated. The influences of CS viscosity, HA content, and crosslinking degree on properties of scaffolds were discussed. SEM images showed that CS/HA scaffolds were porous with short rod-like HA particles dispersing evenly in CS substrate. When [η]CS = 5.75 × 10−4, HA content = 65%, and crosslinking degree = 10%, the resulting CS/HA scaffolds had a flexural strength of 20 MPa and porosity of 60%, which could meet the requirements of bone repair materials. The scaffolds were used as drug carriers for icariin, and the impacts of loading time and crosslinking degree of scaffolds on drug-loading dose were discussed. The suitable loading time was 24 h and it would be better to keep crosslinking degree no more than 10%. The drug release behavior demonstrated that the icariin-loading CS/HA scaffolds could achieve basic drug sustained release effect. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 1539–1547, 2013

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