Layer-by-layer assembled hydrogel nanocomposite film with a high loading capacity
Article first published online: 22 MAY 2013
Copyright © 2013 Wiley Periodicals, Inc.
Journal of Applied Polymer Science
Volume 131, Issue 2, January 15, 2014
How to Cite
2014), Layer-by-layer assembled hydrogel nanocomposite film with a high loading capacity. J. Appl. Polym. Sci., 131, doi: 10.1002/app.39352, , , , , (
- Issue published online: 23 OCT 2013
- Article first published online: 22 MAY 2013
- Manuscript Accepted: 20 MAR 2013
- Manuscript Received: 4 DEC 2012
- National Natural Science Foundation of China. Grant Number: 51163015
- Program for New Century Excellent Talents in University. Grant Number: NCET-11–1072
- drug-delivery systems;
The layer-by-layer assembly technique is a method that widely used in the preparation of nanostructured multilayer ultrathin films. We fabricated a hydrogel nanocomposite film by alternating the deposition of a core–shell poly[(dimethylimino)(2-hydroxy-1,3-propanedily) chloride] (PDMIHPC)–laponite solution and poly(acrylic acid). The growth of the deposition procedure was proven by ultraviolet–visible spectroscopy and spectroscopic ellipsometry. The surface morphology of the films was observed by scanning electron microscopy. The films could reversibly load and release methylene blue (MB) dye, which was used as an indicator. It took about 4.5 h to reach loading equilibrium at pH 9.0. The loading capacity of the film for MB was as large as 4.48 μg/cm2 per bilayer because of the introduction of the core–shell PDMIHPC–laponite as a film component. Nearly 90% of MB was released at pH 3.0 or in a 300 mM NaCl solution within 2.5 h. The loading and release processes were greatly influenced by the ionic strength and pH value of the MB solution. The hydrogel nanocomposite film showed good pH-triggered loading-release reversibility and suggested potential applications in controlled drug-delivery systems and smart materials. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 39352.