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Keywords:

  • biodegradable;
  • polycondensation;
  • biomedical applications;
  • biomaterials;
  • elastomers

ABSTRACT

A novel polymer poly(caprolactone triol succinate) (PPCLSu) was synthesized from monomers polycaprolactone triol and succinic acid by direct polycondensation. The tensile strength of PPCLSu was found to be 0.33 ± 0.03 MPa with an elongation of 47.8 ± 1.9%. These elastomers lost about 7% of their original mass in an in vitro degradation study conducted in phosphate-buffered saline (PBS) at 37°C up to 10 weeks. Three-dimensional (3D) porous scaffolds were created by a porogen-leaching method and these constructs were evaluated for primary rat osteoblast (PRO) proliferation and phenotype development in vitro. This elastomer promoted primary rat osteoblast adhesion, proliferation and increased expression of alkaline phosphatase, an early marker of osteoblastic phenotype. These preliminary results suggest that PPCLSu may be a good candidate material for scaffolding applications in tissue regeneration. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 3770–3777, 2013