To avoid environmental hazards, packaging industries are aiming to produce biodegradable films for food contact safety and its degradation. LLDPE film containing 1% pro-oxidant additive was studied for food compatibility in different simulants, at room temperature conditions as per Bureau of Indian Standards (BIS), code of federal regulations (CFR), food and drug administration USA (USFDA), and European Economic Commission directives (EEC) specifications. Overall migration values were well within the specified limits for food contact applications at room temperature filling and storing. The pro-oxidant loaded LLDPE film was also studied for its degradation behavior with the changes in physical and mechanical properties along with thermal behavior, morphology and infrared spectroscopy. The molecular oxidations of pro-oxidant-loaded LLDPE films are severed which increases hydrophilicity. Evidently, the oxidation renders the material much more vulnerable to microbial attack. The combined effect of both photo and bio degradation is most effective for complete degradation of film. The results obtained from these studies revealed that the fine balance (1%) of pro-oxidant contents in the film guarantees food contact safety and its degradation. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 39756.