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Vitamin E acetate addition to poly(d,l)lactic acid modifies its mechanical behavior without affecting biocompatibility

Authors

  • Pamela Pittarella,

    1. Innovative Research Laboratory for Wound Healing, Health Sciences Department, University of Eastern Piedmont “A. Avogadro,” Via Solaroli 17, Novara, Italy
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  • Diego Antonioli,

    1. Department of Sciences and Technological Innovation, University of Eastern Piedmont “A. Avogadro,” V. Teresa Michel 11, Alessandria, Italy
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  • Manuela Rizzi,

    1. Innovative Research Laboratory for Wound Healing, Health Sciences Department, University of Eastern Piedmont “A. Avogadro,” Via Solaroli 17, Novara, Italy
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  • Michele Laus,

    1. Department of Sciences and Technological Innovation, University of Eastern Piedmont “A. Avogadro,” V. Teresa Michel 11, Alessandria, Italy
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  • Filippo Renò

    Corresponding author
    1. Innovative Research Laboratory for Wound Healing, Health Sciences Department, University of Eastern Piedmont “A. Avogadro,” Via Solaroli 17, Novara, Italy
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ABSTRACT

Mechanical properties of poly(d,l)lactic acid films enriched with Vitamin E and Vitamin E Acetate (5–40% w/w) were investigated. The addition of both formulations resulted in increased polymer Young's modulus and tensile strength. Human foreskin fibroblasts and murine pre-osteoblasts were used to assess the biocompatibility of polymers. Pre-osteoblasts adhesion and proliferation were strongly decreased by Vitamin E, whereas Vitamin E Acetate did not alter cell proliferation. Collagen deposition was lower onto Vitamin E blended polymers than onto native and Vitamin E Acetate blended ones. Fibroblasts adhesion and proliferation were increased by both Vitamin E and Vitamin E Acetate addition. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2014, 131, 39970.

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