Reactive processing is a useful method to improve the compatibility of immiscible polymer blends. Nylon 1010/Ethylene-vinyl acetate rubber (EVM) blends were prepared via melt blending at 240°C and tetrabutyl titanate (Ti(OBu)4) was used as a catalyst. Ester–amide exchange reactions were proven to take place between Nylon and EVM during the shear processing. Melt flow index, Fourier transform infrared spectroscopy, and proton nuclear magnetic resonance spectra were used to study the reactions. It was demonstrated that tuning the shear rate could control the properties and reaction extent of Nylon 1010/EVM/Ti(OBu)4 blends. The results revealed that the reactions were promoted by high shear rate. Tensile strength of the blends increased from 4.5 to 11.4 MPa when the shear rate increased from 20 to 80 rpm. Meanwhile, scanning electron microscopy was adopted to study the morphology of the reactive blends. It was found that the morphology of the blends was changed from sea-island structures to co-continuous structures while increasing the shear rate from 20 to 100 rpm. Dynamic mechanical analysis confirmed that high-shear processing was found to promote the compatibility of the blends. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40064.