Bioactive agarose carbon-nanotube composites are capable of manipulating brain–implant interface
Article first published online: 24 DEC 2013
Copyright © 2013 Wiley Periodicals, Inc.
Journal of Applied Polymer Science
Special Issue: Bioactive Surface Functionalization
Volume 131, Issue 14, July 15, 2014
How to Cite
2014). Bioactive agarose carbon-nanotube composites are capable of manipulating brain–implant interface. J. Appl. Polym. Sci. 131, 40297, doi: 10.1002/app.40297, , , and (
- Issue published online: 16 APR 2014
- Article first published online: 24 DEC 2013
- Manuscript Accepted: 11 DEC 2013
- Manuscript Received: 9 SEP 2013
- functionalization of polymers;
- graphene and fullerenes
Composite electrodes made of the polysaccharide agarose and carbon nanotubes (A-CNE) have shown potential to be applied as tissue-compatible, micro-electronic devices. In this article, A-CNEs were functionalized using neuro-relevant proteins (laminin and alpha-melanocyte stimulating hormone) and implanted in brain tissue for 1 week (acute response) and 4 weeks (chronic response). Qualitative and quantitative analysis of neuronal and immunological responses revealed significant changes in immunological response to implanted materials depending on the type of biomolecule used. The potential to manipulate tissue response through the use of an anti-inflammatory protein, alpha-melanocyte stimulating hormone, was shown in the reduction of astroglia presence near the implant site during the glial scar formation. These results suggest that A-CNEs, which are soft, flexible, and easily made bioactive, have the ability to modify brain tissue response through surface modification as a function of the biomolecule used. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40297.