Poly(HEMA)/cyclodextrin-based hydrogels for subconjunctival delivery of cyclosporin A
Article first published online: 29 JAN 2014
Copyright © 2014 Wiley Periodicals, Inc.
Journal of Applied Polymer Science
Volume 131, Issue 12, June 15, 2014
How to Cite
2014). Poly(HEMA)/cyclodextrin-based hydrogels for subconjunctival delivery of cyclosporin A. J. Appl. Polym. Sci. 131, 40397, doi: 10.1002/app.40397, , and (
- Issue published online: 16 MAR 2014
- Article first published online: 29 JAN 2014
- Manuscript Accepted: 6 JAN 2014
- Manuscript Received: 2 DEC 2013
- cylosporine A;
- subconjunctival delivery;
- sustained release
To enhance the solubility and ocular permeability of immunosuppressive agent, cyclosporine A (CsA), three types of delivery systems were prepared using (2-hydroxypropyl)-β-cyclodextrin (HPβCD), and 2-hydroxyethyl methacrylate (HEMA). Those systems are (i) hydrogels of HPβCD with crosslinking agent ethylene glycol diglycidylether, (ii) poly(HEMA) hydrogels, and (iii) different amounts of HPβCD-containing poly(HEMA) hydrogels indicated as poly(HEMA-co-HPβCD). In the presence of HEMA, hydrogels have desired mechanical integrity with lower equilibrium content than that of hydrogels without HEMA. CsA was loaded into the HPβCD-based hydrogels by embedding from its aqueous suspensions in higher amounts than that of the poly(HEMA) hydrogels that were loaded by CsA–HPβCD complex solution. Although the poly(HEMA) hydrogels are releasing total CsA in 3 days, long-term release was realized from HPβCD-based hydrogels. For subconjunctival administration, regarding to the amounts of loaded CsA, release profiles, and mechanical integrity, the most suitable system is poly(HEMA-co-HPβCD) hydrogels in high HPβCD content. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40397.