Back Cover, Volume 131, Issue 14



To transform standard flat polystyrene surfaces into textured microenvironments for three-dimensional (3D) cell cultures, Michael E. DeRosa, Yulong Hong, Ronald A. Faris, and Hongwei Rao describe a solvent treatment process. Cell culture experiments typically use thermoplastic plates that have 2D well bottoms. A 3D cell culture plate made of polystyrene in a conventional, inexpensive format could be an attractive technology since cultures could then be conducted on the same material as cell biologists have been using for decades. The study demonstrates that microtextured polystyrene surfaces for 3D cell cultures can easily be made with off-the-shelf microplates by a simple solvent treatment process. DOI: 10.1002/app.40181