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The unique physicochemical properties of the zein protein have led to a wide variety of applications in different industries, especially in the fields of food and biomedicine. The investigation of zein-based delivery systems is of particular interest for hydrophobic drugs and nutrients. In their review, Yangchao Luo and Qin Wang summarize the technological strategies of fabrication techniques for zein-based micro- and nano-particles and their delivery applications. Given the fast-growing field of zein-based delivery systems, they anticipate that the development of advanced zein-based micro- and nano-structured delivery systems will expand to new applications. (DOI: 10.1002/app.40696)