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Surface modification of electrospun chitosan nanofibrous mats for antibacterial activity

Authors

  • Wiyong Kangwansupamonkon,

    1. National Nanotechnology Center, National Science and Technology Development Agency, Klong Luang, Pathumthani, Thailand
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  • Walaiwan Tiewtrakoonwat,

    1. Program of Petrochemistry and Polymer Science, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok, Thailand
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  • Pitt Supaphol,

    1. The Petroleum and Petrochemical College and The Center of Excellence on Petrochemical and Materials Technology (PETROMAT), Chulalongkorn University, Pathumwan, Bangkok, Thailand
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  • Suda Kiatkamjornwong

    Corresponding author
    1. Program of Petrochemistry and Polymer Science, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok, Thailand
    2. Division of Science, The Royal Institute of Thailand, Dusit, Bangkok, Thailand
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ABSTRACT

Chitosan (CS) blended with poly(ethylene oxide) (PEO) was electrospun into nanofibrous mats. The spinning solution of 6.7 : 0.3 (% w/v) of CS : PEO was dissolved in a 70 : 30 (v/v) trifluoroacetic acid/dichloromethane solution. The obtained fibers were smooth without beads on their surfaces and average diameter of the fiber was 272 ± 56 nm. N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride (HTACC) and N-benzyl-N,N-dimethyl chitosan iodide (QBzCS) were each prepared from the CS/PEO mats. They were identified by Fourier-transform infrared and X-ray photoelectron spectroscopy and degree of swelling in water. Both quaternized electrospun chitosan mats exhibited superior antibacterial activity to the unmodified electrospun CS/PEO against Staphylococcus aureus and Escherichia coli at short contact times. After 4 h of contact, the reduction of both bacterial strains by CS/PEO, HTACC, and QBzCS was equal at about 99–100%. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40981.

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