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Synthesis and properties of a polymerizable quaternary ammonium salt

Authors

  • Wei Zhou,

    1. State Key Laboratory of Military Stomatology, Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China
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    • Wei Zhou and Ke-Qiang Ma contributed equally to this work.

  • Ke-Qiang Ma,

    1. Department of Stomatology, Wuhan General Hospital of Guangzhou Military Command of PLA, Wuhan, China
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    • Wei Zhou and Ke-Qiang Ma contributed equally to this work.

  • Li-Hui Tang,

    1. State Key Laboratory of Military Stomatology, Department of Dental Materials, School of Stomatology, Fourth Military Medical University, Xi'an, China
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  • Fang Li,

    1. State Key Laboratory of Military Stomatology, Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China
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  • Li Huang,

    1. State Key Laboratory of Military Stomatology, Department of Department of General Dentistry and Emergency, School of Stomatology, Fourth Military Medical University, Xi'an, China
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  • Ji-Hua Chen

    Corresponding author
    1. State Key Laboratory of Military Stomatology, Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China
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ABSTRACT

Novel polymerizable monomer N,N-dimethyl-2-[(2-methylacryloyl)oxy] ethanaminium 5-carboxy-2,4-bis benzoate (DMAEMA-PMDPM salt) was synthesized by acid-alkali neutralizing reaction and was proved to be successful by Fourier transform infrared spectroscopy. The antibacterial activity and cytotoxicity of monomer were assessed by determination of the minimal inhibitory concentration and minimal bactericidal concentration, time–kill study and methyltetrazolium test assay. Polymerizable efficiency was determined by measurement of degree of conversion. The results indicated that DMAEMA-PMDPM salt which is a kind of liquid polymerizable has some antimicrobial activity and similar cytotoxicity to common dental resin monomers. The new monomer also has a high polymerizable ability. Therefore it might have a great potential to prepare antimicrobial coatings on denture base and soft lining materials, as well as some biomedical applications. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 41002.

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