Polymeric PEGylated nanoparticles as drug carriers: How preparation and loading procedures influence functional properties
Article first published online: 13 AUG 2014
© 2014 Wiley Periodicals, Inc.
Journal of Applied Polymer Science
Volume 132, Issue 3, January 15, 2015
How to Cite
2015), Polymeric PEGylated nanoparticles as drug carriers: How preparation and loading procedures influence functional properties. J. Appl. Polym. Sci., 132, 41310, doi: 10.1002/app.41310(
- Issue published online: 17 OCT 2014
- Article first published online: 13 AUG 2014
- Manuscript Accepted: 20 JUL 2014
- Manuscript Received: 3 JAN 2014
- drug delivery systems;
- nanostructured polymers;
- nanowires and nanocrystals
The application of emerging nanotechnologies in medicine showed in the last years a significant potential in the improvement of therapies. In particular, polymeric nanocarriers are currently tested to evaluate their capability to reduce side effects, to increase the residence time in the body and also to obtain a controlled release over time. In the present work a novel polymeric nanocarrier was developed and optimized to obtain, with the same chemical formulation, three different typologies of nanocarriers: dense nanospheres loaded with an active molecule (1) during nanoparticle formation and (2) after the preparation and (3) hollow nanocapsules to increase the starting drug payload. Synthetic materials considered were PEGylated acrylic copolymers, folic acid was used as model of a hydrophobic drug. The main aim is to develop an optimized nanocarrier for the transport and the enhanced release of poorly water-soluble drugs. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41310.