Ganglionic eminence of the human fetal brain—new vistas
Article first published online: 6 MAY 2002
Copyright © 2002 Wiley-Liss, Inc.
The Anatomical Record
Volume 267, Issue 3, pages 191–195, 1 July 2002
How to Cite
Ulfig, N. (2002), Ganglionic eminence of the human fetal brain—new vistas. Anat. Rec., 267: 191–195. doi: 10.1002/ar.10104
- Issue published online: 6 MAY 2002
- Article first published online: 6 MAY 2002
- Manuscript Accepted: 19 FEB 2002
- Manuscript Received: 27 JUL 2001
- gangliothalamic body;
- preterm infants;
This review deals with recent findings concerning the complex functions of the ganglionic eminence (GE), which represents a conspicuous domain of the telencephalic proliferative zone and persists nearly throughout fetal life. The GE not only contains precursor neurons of the basal ganglia, it also contributes significantly to the population of interneurons in the cerebral cortex and to a population of thalamic neurons. The latter migrate through a distinct transient structure, the gangliothalamic body (GTB). The GE also represents an intermediate target for growing thalamic axons (on their way to the cerebral cortex) and cortical axons (on their way to the thalamus). In developmental neuropathology the GE plays an important role in prematurely born infants. The pathogenesis of GE bleedings is discussed with regard to the abundant expression of interleukin-6 (IL-6) receptors on GE cells. The consequences of such bleedings are discussed in view of cellular responses, such as the induction of leukemia inhibitory factor (LIF) expression in GE cells after hemorrhage. Anat Rec 267:191–195, 2002. © 2002 Wiley-Liss, Inc.