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Abstract

Typical immature pubic joints developed when undifferentiated mesenchyme from the pelvic region of 13-day-old embryos was grown in vitro on a Millipore filter. After five days the joints were transplanted to 5-day-old postnatal female mice whose pubic joints were excised prior to transplantation. The transplanted joints developed to adult-type symphyses and replaced the excised joints of the recipients. Typical bone resorption and cartilage transformation to ligamentous tissue occurred in transplanted joints in pregnant recipients.