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Abstract

The Gomori (metal-salt) and azo-dye techniques were used for the localization of alkaline and acid phosphatases in the metanephric kidneys from 13- to 22-day-old fetal rats. Alkaline phosphatase activity was localized first in the luminal (brush) border of the differentiated proximal tubule in the kidneys of 19-day-old fetuses. Acid phosphatase activity was first localized in the cytoplasm of all the morphologically differentiated cells of the nephron in the kidneys of 20-day-old fetuses as cytoplasmic “droplets.” The relationships of the localization of these to the morphological differentiation of the nephron is discussed.