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Abstract

Injections of 0.25 mg estradiol benzoate and 1.25 mg testosterone propionate in five day old intact and spayed albino female rats either eliminated or shortened the period of the estral activity cycle. Greater than normal amplitude of running was associated with neonatal estrogen and lower than normal activity with androgen. All of the oil- but none of the steroid-treated females exhibited normal receptivity to vigorous males after hormone replacement therapy. It was concluded that neonatally administered steroids modified neural centers mediating behavioral periodicity and mating as well as those involved in gonadotrophin release.