This study was supported by Research grant HD 00867–03 from the National Institute of Child Health and Human Development, United States Public Health Service. Grateful acknowledgment is made to Dr. Paul W. Fox for aiding in collecting activity wheel data, Mr. Stephen F. Bollinger for assisting in making observations, and Dr. Gary C. Galbraith for programming the data for computer analysis.
Effects of early postnatal androgen and estrogen injections on the estrous activity cycles and mating behavior of rats†
Article first published online: 27 JAN 2005
Copyright © 1967 Wiley-Liss, Inc.
The Anatomical Record
Volume 157, Issue 1, pages 97–104, January 1967
How to Cite
Gerall, A. A. (1967), Effects of early postnatal androgen and estrogen injections on the estrous activity cycles and mating behavior of rats. Anat. Rec., 157: 97–104. doi: 10.1002/ar.1091570114
- Issue published online: 27 JAN 2005
- Article first published online: 27 JAN 2005
Injections of 0.25 mg estradiol benzoate and 1.25 mg testosterone propionate in five day old intact and spayed albino female rats either eliminated or shortened the period of the estral activity cycle. Greater than normal amplitude of running was associated with neonatal estrogen and lower than normal activity with androgen. All of the oil- but none of the steroid-treated females exhibited normal receptivity to vigorous males after hormone replacement therapy. It was concluded that neonatally administered steroids modified neural centers mediating behavioral periodicity and mating as well as those involved in gonadotrophin release.