The morphology of valves in cerebral arteries of the rat


  • William C. Rosen

    1. Department of Anatomy, University of North Dakota, Grand Forks, North Dakota
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    • Predoctoral Fellow 1-F1-GM-29,120-01, National Institutes of Health, United States Public Health Service.

  • Supported by grant HE 09041 from the National Institutes of Health, United States Public Health Service, under the direction of Dr. Frank N. Low.


Valves associated with major arterial branches at the base of the brain in rats were studied after fixation by perfusion with buffered aldehydes. These endothelial covered structures are entirely intimal. All cellular and non-cellular elements of their core are laminated, including the PAS positive ground substance. Smooth muscle and nerve endings are not demonstrable. Reticular fibers form a substantial sheath around the base of each valve. Their location and morphology suggest that they may serve a regulatory function in maintaining proper intracerebral blood flow.