Predoctoral Trainee in the Anatomical Sciences (5T1 GM 287).
Arteritis of coronary arteries in mice receiving a single dose of cortisone†
Article first published online: 27 JAN 2005
Copyright © 1968 Wiley-Liss, Inc.
The Anatomical Record
Volume 160, Issue 1, pages 1–11, January 1968
How to Cite
Ashburn, A. D., Williams, W. L. and Smith-Vaniz, G. T. (1968), Arteritis of coronary arteries in mice receiving a single dose of cortisone. Anat. Rec., 160: 1–11. doi: 10.1002/ar.1091600102
Supported by grants from the National Institutes of Health, U.S.P.H.S., HE-04052 and Institutional Research grant (GR 00287), and from the Mississippi Heart Association.
- Issue published online: 27 JAN 2005
- Article first published online: 27 JAN 2005
Mice were given a single injection of cortisone acetate and killed from one to seven days later. Arterial lesions occurred first and were predominantly located in the right ventricle. Hyalin was present in media of these coronary arteries within 24 hours following administration of cortisone. Exudative and proliferative changes in the arterial walls and perivascular spaces followed medial hyalinization. The highest incidence of arterial lesions (90%) was attained on the third day following cortisone injection and then decreased slightly (57%) by the seventh day. Myocardial necrosis was observed first in mice killed 48 hours after receiving cortisone and the incidence did not change significantly thereafter.