A histochemical study of neuro-insular complexes in the pancreas of the rat
Article first published online: 27 JAN 2005
Copyright © 1968 Wiley-Liss, Inc.
The Anatomical Record
Volume 160, Issue 2, pages 231–237, February 1968
How to Cite
Morgan, C. R. and Lobl, R. T. (1968), A histochemical study of neuro-insular complexes in the pancreas of the rat. Anat. Rec., 160: 231–237. doi: 10.1002/ar.1091600209
- Issue published online: 27 JAN 2005
- Article first published online: 27 JAN 2005
Neuro-insular complexes (neural elements in juxtaposition to islet cells of the pancreas) were studied in Holtzman albino rats.
Pancreases were stained by either the aldehyde-fuchsin-ponceau (A-F-P) or the acetylcholinesterase (ACHE) technique. The A-F-P stain gave good definition of islet structure. Although some nerve cell bodies were distinguishable with this stain, the AChE technique gave better definition of nerve cells, including interstitial cells of Cajal.
In adult rats every islet examined had a nerve network. In newborns the nerve network was less apparent though some nerve elements were present. A nerve network typical of the adult was found in rats 48 hours after birth.
Following insulin and glucose loading, variation in the localization of AChE was noted. It is suggested that neuro-insular complexes have a modulatory influence on release of hormones.