Supported by grants FR 5353-04-5 and 1 RO1-HD-01679-02 of the USPHS National Institutes of Health.
Studies on the experimental induction of overgrowth in chick embryos†
Article first published online: 3 FEB 2005
Copyright © 1968 Wiley-Liss, Inc.
The Anatomical Record
Volume 161, Issue 4, pages 419–425, August 1968
How to Cite
Burda, D. J. (1968), Studies on the experimental induction of overgrowth in chick embryos. Anat. Rec., 161: 419–425. doi: 10.1002/ar.1091610403
- Issue published online: 3 FEB 2005
- Article first published online: 3 FEB 2005
An analysis has been made of the experimental conditions under which overgrowth can be produced in the brains of chick embryos. A total of 122 individuals were obtained from six series of embryos subjected to varying degrees of surgical manipulation involving the anterior rhombomere and/or its substratum. The results indicate that in addition to the cases of overgrowth obtained by the standard technique of removing the entire anterior rhombomere, overgrowth could also be successfully induced when a portion of the chordamesoderm underlying the anterior rhombomere was either removed or merely dissociated from the neural tissue, while leaving the latter relatively intact. In embryos in which the roof and sides of the anterior rhombomere were removed, overgrowth could not be obtained in the absence of damage to the substratum.