This investigation was supported by United States Public Health Service research grants HE09311, 2T1 GM382-06, and HE06943.
Fine structure of canine Kupffer cells and their microtubule-containing cytosomes†
Article first published online: 23 FEB 2005
Copyright © 1969 Wiley-Liss, Inc.
The Anatomical Record
Volume 163, Issue 4, pages 483–496, April 1969
How to Cite
Boler, R. K. (1969), Fine structure of canine Kupffer cells and their microtubule-containing cytosomes. Anat. Rec., 163: 483–496. doi: 10.1002/ar.1091630401
- Issue published online: 23 FEB 2005
- Article first published online: 23 FEB 2005
- Manuscript Accepted: 18 NOV 1968
- Manuscript Received: 28 JUN 1968
The ultrastructure of Kupffer cells of canine liver has been studied and described. Kupffer cell nuclei were elongated and irregular in shape having a prominent double nuclear envelope containing scattered ribosomes on the outer membrane. Mitochondria were small, relatively scarce, and contained few mitochondrial granules. Elements of endoplasmic reticulum were scarce and highly irregular in form. In general, the cytoplasm was less dense than hepatocytes and contained fewer organelles which were less compactly arranged than in hepatocytes. Microbodies were not observed in any of the Kupffer cells studied. The cytoplasm contained various numbers of large phagosomes but consistently contained numerous dense cytosomes of various sizes. The most striking finding was that many cytosomes and phagosomes contained large numbers of short microtubules approximately 350 Å in diameter which were arranged in clusters and were associated with membanes.