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Abstract

Specialized intercellular junctions have been observed in 3-methylcholanthrene-induced mouse sarcomas. These junctions are of two morphologic types and appear to be focal in nature. The first type consists of an approximation of the plasma membranes of adjacent cells to within 200 Å of one another. In the junctional region the intercellular space and the adjacent cytoplasm are of increased density. The second type of junction is more complex, the intercellular space being of greater width and containing a dense central plaque. The intercellular space and the adjacent cytoplasm are of increased density. Such junctions may serve a role in structural support of the tumor mass.