Department of Anatomy, University of Tennessee Medical Units, Memphis, Tennessee 38103.
Effects of sex hormones on diet-induced atrial thrombosis†
Article first published online: 27 JAN 2005
Copyright © 1970 Wiley-Liss, Inc.
The Anatomical Record
Volume 168, Issue 3, pages 331–337, November 1970
How to Cite
Wilson, J. L., Ashburn, A. D. and Williams, W. L. (1970), Effects of sex hormones on diet-induced atrial thrombosis. Anat. Rec., 168: 331–337. doi: 10.1002/ar.1091680301
Supported by grants from the National Institutes of Health, U.S.P.H.S. (HE 04052 and RR 05423) and Institutional Research grant (GR 00287).
- Issue published online: 27 JAN 2005
- Article first published online: 27 JAN 2005
- Manuscript Accepted: 29 MAY 1970
- Manuscript Received: 17 JUL 1968
Male and female Taconic Swiss mice were fed a high-fat (28%), low-protein (8%), hypolipotropic diet. Intact mice and gonadectomized mice, with and without injections of estrone or testosterone phenylacetate were studied.
The sex of the animals did not alter the incidence or type of diet-induced cardiovascular lesions. During the 6–12 weeks of feeding thrombi developed in the atrial lumina of 75%–88% of intact and gonadectomized male and female mice. The only prominent decrease in the incidence of such thrombosis was in gonadectomized animals of both sexes receiving estrone where it was reduced to 6%–16%. In castrated males receiving injections of testosterone phenylacetate (Perandren) the incidence of thrombosis was 65%.