Development of seminal vesicles and coagulating glands in neonatal mice. I. The morphogenetic effects of various hormonal conditions
Article first published online: 8 FEB 2005
Copyright © 1981 Wiley-Liss, Inc.
The Anatomical Record
Volume 199, Issue 1, pages 73–88, January 1981
How to Cite
Lung, B. and Cunha, G. R. (1981), Development of seminal vesicles and coagulating glands in neonatal mice. I. The morphogenetic effects of various hormonal conditions. Anat. Rec., 199: 73–88. doi: 10.1002/ar.1091990108
- Issue published online: 8 FEB 2005
- Article first published online: 8 FEB 2005
- Manuscript Accepted: 11 JUN 1980
- Manuscript Received: 17 JUL 1978
Seminal vesicles (SV) and coagulating glands (CG) from neonatal mice 1- to 7-days old were observed in whole mount preparations. Untreated, normal SV developed elaborate epithelial branches beginning on day 3 with secondary branches appearing on day 6. Castration (C), estradiol treatment (E), and castration combined with estradiol treatment (C + E) inhibited the morphogenesis of the epithelial branches. Untreated CG formed solid epithelial stalks that developed lateral epithelial buds on day 3 which attained a complex morphological pattern by day 7. Treatment groups (C, E, and C + E) displayed a pattern of retarded growth with few epithelial buds appearing even at day 7. The effects of castration on both SV and CG were reversed by the addition of testosterone. Short term in vitro culture of 1-day-old SV and CG glands in control medium or medium supplemented with estradiol did not exhibit visible growth. Culture of SV and CG glands with testosterone or a piece of testis showed pronounced development.