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Abstract

Development of Harderian gland of larvae of Rana japonica, Bufo bufo japonicus, and Xenopus laevis was studied. In the adult animals, welldeveloped Harderian glands were invariably present in the orbit. In Rana and Bufo, the gland first appeared at late prometamorphic stage and in Xenopus it appeared around climax stage.

In thyroidectomized tadpoles of Bufo and Rana, the Harderian gland was induced by thyrozine. In hypophysectomized tadpoles of Bufo the gland developed when they were treated with thyrozine or TSH.