Immunohistochemical study of C cell follicles in dog thyroid glands
Article first published online: 8 FEB 2005
Copyright © 1982 Wiley-Liss, Inc.
The Anatomical Record
Volume 204, Issue 1, pages 55–60, September 1982
How to Cite
Kameda, Y. (1982), Immunohistochemical study of C cell follicles in dog thyroid glands. Anat. Rec., 204: 55–60. doi: 10.1002/ar.1092040108
- Issue published online: 8 FEB 2005
- Article first published online: 8 FEB 2005
- Manuscript Accepted: 25 MAY 1982
- Manuscript Received: 12 FEB 1982
In dog thyroid glands there are C cell follicles which are lined solely by C cells and which accumulate a colloidlike substance in the luminal cavities. In order to clarify the properties of the colloidlike substance secreted by C cells, the C cell follicles were stained with PAS reaction and immunoperoxidase method using anticalcitonin, anti-C-thyroglobulin, and anti-19S-thyroglobulin antisera, respectively. The colloidlike substance was PAS positive and revealed the strong immunoreaction for C-thyroglobulin but a faint reaction for calcitonin. It was nonreactive with anti-19-thyroglobulin antiserum. These results confirm that C cells synthesize the glycoprotein immunoreactive to anti-C-thyroglobulin antiserum in addition to calcitonin and can store it in the follicular lumens.