Somatostatin immunoreactive C cells in thyroid glands from various mammalia species
Article first published online: 22 FEB 2005
Copyright © 1982 Wiley-Liss, Inc.
The Anatomical Record
Volume 204, Issue 2, pages 161–170, October 1982
How to Cite
Kameda, Y., Oyama, H., Endoh, M. and Horino, M. (1982), Somatostatin immunoreactive C cells in thyroid glands from various mammalia species. Anat. Rec., 204: 161–170. doi: 10.1002/ar.1092040210
- Issue published online: 22 FEB 2005
- Article first published online: 22 FEB 2005
- Manuscript Accepted: 7 JUL 1982
- Manuscript Received: 16 APR 1982
The relative distribution of somatostatin- and calcitonin-containing cells in thyroid glands from various mammalian species was investigated by immunoperoxidase staining, and the concentration of immunoreactive somatostatin by radioimmunoassay. In the thyroid glands of guinea pigs and rabbits, most of the calcitonin cells were also immunoreactive to the somatostatin antiserum, and high concentration of immunoreactive somatostatin was obtained. On the other hand, in the thyroids of other animal species—rats, dogs, pigs, cows, goats, cats, monkeys, mice, and hamsters—only a few C cells revealed the immunoreaction for somatostatin, and the concentration of somatostatin was low. In all animal species studied, the somatostatin was present in the same cells that contain calcitonin, though in guinea pigs and rats there were some C cells containing a large number of reaction products for somatostatin but very few for calcitonin. Thus, it was concluded that there was a considerable variation in somatostatin immunoreactivity of thyroid C cells from species to species.