Neurulation in the mouse: Manner and timing of neural tube closure
Article first published online: 26 JAN 2005
Copyright © 1989 Wiley-Liss, Inc.
The Anatomical Record
Volume 223, Issue 2, pages 194–203, February 1989
How to Cite
Sakai, Y. (1989), Neurulation in the mouse: Manner and timing of neural tube closure. Anat. Rec., 223: 194–203. doi: 10.1002/ar.1092230212
- Issue published online: 26 JAN 2005
- Article first published online: 26 JAN 2005
- Manuscript Accepted: 10 MAY 1988
- Manuscript Received: 15 DEC 1987
The manner and timing of neural fold fusion in primary neurulation were studied in 1,575 normal ICR mouse embryos by using binocular dissecting, light, and scanning electron microscopy.
The initial fusion of apposing neural folds occurred at the level of the intermediate point between the third and fourth somites (i.e., in the caudal myelencephalon) and proceeded both rostrally and caudally. A second fusion occurred at what was originally the rostral end of the neural plate and proceeded rostrodorsally. A third fusion occurred in the caudal diencephalon and proceeded both rostrally and caudally. This was followed by complete closure of the telencephalic neuropore at the midpoint of the telencephalic roof and then complete closure of the metencephalic neuropore at the rostral part of the metencephalic roof. A fourth fusion occurred at what was originally the caudal end of the neural plate and proceeded rostrally. Finally, the caudal neuropore completely closed at the level of the caudal end of the future 33rd somite.