Glomerular number and size in relation to age, kidney weight, and body surface in normal man
Article first published online: 26 JAN 2005
Copyright © 1992 Wiley-Liss, Inc.
The Anatomical Record
Volume 232, Issue 2, pages 194–201, February 1992
How to Cite
Nyengaard, J. R. and Bendtsen, T. F. (1992), Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat. Rec., 232: 194–201. doi: 10.1002/ar.1092320205
- Issue published online: 26 JAN 2005
- Article first published online: 26 JAN 2005
- Manuscript Accepted: 3 SEP 1991
- Manuscript Received: 14 JAN 1991
The number and size of glomeruli in normal, mature human kidneys were estimated by a direct and unbiased stereological method, the fractionator. The number was 617,000 on average, and the mean size 6.0 M μm3. Both glomerular number and size showed significant negative correlation to age and significant positive correlation to kidney weight. Apparently, humans loose glomeruli with age.
Body surface area correlated positively to kidney weight and total glomerular volume but not to number of glomeruli. Body surface area correlates significantly with metabolic rate (Robertson and Reid, Lancet, 1: 940–943, 1952). Thus, intraspecies adaptation of kidney filtration capacity to the metabolic demand is performed by changing the size of glomeruli, i. e., the number of glomeruli in individuals of a given species is independent of the metabolic rate.