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An in vivo Look at Vertebrate Liver Architecture: Three-Dimensional Reconstructions from Medaka (Oryzias latipes)
Article first published online: 21 MAY 2007
Copyright © 2007 Wiley-Liss, Inc.
The Anatomical Record
Volume 290, Issue 7, pages 770–782, July 2007
How to Cite
Hardman, R. C., Volz, D. C., Kullman, S. W. and Hinton, D. E. (2007), An in vivo Look at Vertebrate Liver Architecture: Three-Dimensional Reconstructions from Medaka (Oryzias latipes). Anat Rec, 290: 770–782. doi: 10.1002/ar.20524
- Issue published online: 11 JUN 2007
- Article first published online: 21 MAY 2007
- Manuscript Accepted: 20 FEB 2007
- Manuscript Received: 11 JUL 2006
- NIH (NCRR). Grant Number: 1 RO1 RR018583-02
- National Institute of Health (NIH/NCI). Grant Number: R21CA106084-01A1
- National Center for Research Resources, a component of the National Institutes of Health
- liver architecture;
- comparative hepatology;
- 3-dimensional structure;
- liver structure and function
Understanding three-dimensional (3D) hepatobiliary architecture is fundamental to elucidating structure/function relationships relevant to hepatobiliary metabolism, transport, and toxicity. To date, factual information on vertebrate liver architecture in 3 dimensions has remained limited. Applying noninvasive in vivo imaging to a living small fish animal model we elucidated, and present here, the 3D architecture of this lower vertebrate liver. Our investigations show that hepatobiliary architecture in medaka is based on a polyhedral (hexagonal) structural motif, that the intrahepatic biliary system is an interconnected network of canaliculi and bile-preductules, and that parenchymal architecture in this lower vertebrate is more related to that of the mammalian liver than previously believed. The in vivo findings presented advance our comparative 3D understanding of vertebrate liver structure/function, help clarify previous discrepancies among vertebrate liver conceptual models, and pose interesting questions regarding the “functional unit” of the vertebrate liver. Anat Rec, 2007. © 2007 Wiley-Liss, Inc.