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Bifurcation Model for Characterization of Pulmonary Architecture
Article first published online: 28 JAN 2008
Copyright © 2008 Wiley-Liss, Inc.
The Anatomical Record
Volume 291, Issue 4, pages 379–389, April 2008
How to Cite
Lee, D., Park, S. S., Ban-Weiss, G. A., Fanucchi, M. V., Plopper, C. G. and Wexler, A. S. (2008), Bifurcation Model for Characterization of Pulmonary Architecture. Anat Rec, 291: 379–389. doi: 10.1002/ar.20643
- Issue published online: 21 MAR 2008
- Article first published online: 28 JAN 2008
- Manuscript Accepted: 16 NOV 2007
- Manuscript Received: 3 SEP 2007
- United States Environmental Protection Agency. Grant Number: RD-83241401-0
- Philip Morris USA Inc.
- Philip Morris International
- lung airway;
- bifurcation model;
- anatomical branched structures;
- CT image;
- simulated annealing method
A flexible mathematical model of an asymmetric bronchial airway bifurcation is presented. The bifurcation structure is automatically determined after the user specifies geometric parameters: radius of parent airway, radii of daughter airways, radii of curvature of the daughter branch toroids, bifurcation angles, and radius of curvature of carina ridge. Detailed shape in the region where the three airways merge is defined by several explicit functions and can be changed with ease in accordance with observed lung structure. These functions take into account the blunt shape of the carina, the smooth transition from the outer transition zone to the inner one, and the shift in carinal ridge starting position as a function of bifurcation asymmetry. We validated the bifurcation model by comparing it to a computed tomography image of a rat lung cast. Three-dimensional representations of the bifurcation geometry can be viewed at http://mae.ucdavis.edu/wexler/lungs/bifurc.htm. Anat Rec, 291:379–389, 2008. © 2008 Wiley-Liss, Inc.