Artificial Circulation of the Liver: Machine Perfusion as a Preservation Method in Liver Transplantation
Article first published online: 16 MAY 2008
Copyright © 2008 Wiley-Liss, Inc.
The Anatomical Record
Volume 291, Issue 6, pages 735–740, June 2008
How to Cite
Vekemans, K., Liu, Q., Pirenne, J. and Monbaliu, D. (2008), Artificial Circulation of the Liver: Machine Perfusion as a Preservation Method in Liver Transplantation. Anat Rec, 291: 735–740. doi: 10.1002/ar.20662
- Issue published online: 16 MAY 2008
- Article first published online: 16 MAY 2008
- Manuscript Accepted: 19 DEC 2007
- Manuscript Received: 4 JUN 2007
- Institute for Science and Technology (IWT). Grant Number: IWT 040350
- CAF, Vilvoorde, Belgium
- machine perfusion;
Due to the sharp increase in liver transplant candidates and the subsequent shortage of suitable donor livers, an extension of the current donor criteria is necessary. Simple cold storage, the current standard in organ preservation has proven to be insufficient to preserve extended criteria donor livers. Therefore a renewed interest grew toward alternative methods for liver preservation, such as hypothermic machine perfusion and normothermic machine perfusion. These “new” preservation methods were primarily assessed in rat models, and only a few clinically relevant large animal models have been described so far. This review will elaborate on these alternative preservation methods. Anat Rec, 291:735–740, 2008. © 2008 Wiley-Liss, Inc.