Pulmonary Architecture in the Conducting Regions of Six Rats

Authors

  • Dongyoub Lee,

    Corresponding author
    1. Department of Mechanical and Aeronautical Engineering, University of California, Davis, California
    • Mechanical and Aeronautical Engineering, One Shields Avenue, University of California, Davis, CA 95616
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    • Fax: 530-754-4962.

  • Michelle V. Fanucchi,

    1. Department of Anatomy, Physiology, and Cell Biology, University of California, Davis, California
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  • Charles G. Plopper,

    1. Department of Anatomy, Physiology, and Cell Biology, University of California, Davis, California
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  • Jennifer Fung,

    1. Center For Molecular and Genomic Imaging, University of California, Davis, California
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  • Anthony S. Wexler

    1. Department of Mechanical and Aeronautical Engineering, University of California, Davis, California
    2. Department of Civil and Environmental Engineering, University of California, Davis, California
    3. Department of Land, Air and Water Resources, University of California, Davis, California
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Abstract

Rats are widely used for studies of pulmonary toxicology and lung disease. Several studies suggest nominal geometric parameters describing the architecture of the rat airway. However, intersubject variance has never been reported due to the huge effort and time to take these manual measurements. In this study, we present statistics of the branching pattern of six healthy male Sprague Dawley rats by automatically analyzing computed tomography images of silicon casts of their airways. Details of branching characteristics and also intersubject variance are presented. In addition, this study shows that mean and standard deviation of many geometric parameters insufficiently represent pulmonary architecture because some, such as diameter-asymmetry, are not normally distributed. Detailed statistics including inter- and intrasubject variance and distribution of the geometric parameters will aid in constructing more realistic airway models for particle transport and studies of normal and abnormal respiratory physiology. Anat Rec, 291:916–926, 2008. © 2008 Wiley-Liss, Inc.

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