Pulmonary Biology

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Platelet-Derived Growth Factor Receptor-Alpha-Expressing Cells Localize to the Alveolar Entry Ring and Have Characteristics of Myofibroblasts During Pulmonary Alveolar Septal Formation†

  1. Stephen E. McGowan‡,*,
  2. Ruth E. Grossmann,
  3. Patricia W. Kimani,
  4. Amey J. Holmes

Article first published online: 2 OCT 2008

DOI: 10.1002/ar.20764

Issue

The Anatomical Record

The Anatomical Record

Volume 291, Issue 12, pages 1649–1661, December 2008

Additional Information

How to Cite

McGowan, S. E., Grossmann, R. E., Kimani, P. W. and Holmes, A. J. (2008), Platelet-Derived Growth Factor Receptor-Alpha-Expressing Cells Localize to the Alveolar Entry Ring and Have Characteristics of Myofibroblasts During Pulmonary Alveolar Septal Formation. Anat Rec, 291: 1649–1661. doi: 10.1002/ar.20764

Author Information

  1. Research Service, Iowa City Department of Veterans Affairs Medical Center, University of Iowa Carver College of Medicine, Iowa City, Iowa

  1. ‡

    Fax: 319-353-6406.

*Division of Pulmonary, Critical Care, and Occupational Medicine, Department of Internal Medicine, C33B-GH, University of Iowa Hospitals and Clinics, 200 Hawkins Dr., Iowa City, IA 52242

  1. †

    This article is a US Government work and, as such, is in the public domain in the United States of America.

  2. ‡

    Fax: 319-353-6406.

Publication History

  1. Issue published online: 25 NOV 2008
  2. Article first published online: 2 OCT 2008
  3. Manuscript Accepted: 26 JUN 2008
  4. Manuscript Received: 11 MAR 2008

Funded by

  • Department of Veterans Affairs Research Service

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LITERATURE CITED

  • Awonusonu F,Srinivasan S,Strange J,Al Jumaily W,Bruce MC. 1999. Developmental shift in the relative percentages of lung fibroblast subsets: role of apoptosis postseptation. Am J Physiol 277: L848–L859.
  • Bedner E,Ruan Q,Chen S,Kaminski LA,Darzynkiewicz Z. 2000. Multiparameter analysis of progeny of individual cells by laser scanning cytometry. Cytometry 40: 271–279.
    Direct Link:
  • Bostrom H,Gritli-Linde A,Betsholtz C. 2002. PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis. Dev Dyn 223: 155–162.
    Direct Link:
  • Bostrom H,Willetts K,Pekny M,Leveen P,Lindahl P,Hedstrand H,Pekna M,Hellstrom M,Gebre-Medin S,Schalling M,Nilsson M,Kurland S,Tornell J,Heath JK,Betsholtz C. 1996. PGDF-A signaling is a critical event is lung alveolar myofibroblast development and alveogenesis. Cell 85: 863–873.
  • Breitkopf K,van Roeyen C,Sawitza I,Wickert L,Floege J,Gressner AM. 2005. Expression patterns of PDGF-A, -B, -C, and-D and the PDGF-receptors α and β in activated rat hepatic stellate cells (HSC). Cytokine 31: 349–357.
  • Burgess HA,Daugherty LE,Thatcher TH,Lakatos HF,Ray DM,Redonnet M,Phipps RP,Sime PJ. 2005. PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis. Am J Physiol 288: L1146–L1153.
  • Burri P,Schittny JC. 2004. Morphogenesis of the mammalian lung: aspects of structure and extracellular matrix. In: MassaroDJ,MassaroGD,ChambonP, editors. Lung development and regeneration. New York: Marcel Dekker. p 275–310.
  • Burri PH. 1974. The postnatal growth of the rat lung. III. Morphology. Anat Rec 180: 77–98.
    Direct Link:
  • Burri PH. 2006. Structural aspects of postnatal lung development-alveolar formation and growth. Biol Neonate 89: 313–322.
  • Davis BH,Coll D,Beno DW. 1993. Retinoic acid suppresses the response to platelet-derived growth factor in human hepatic Ito-cell-like myofibroblasts: a post-receptor mechanism independent of raf/fos/jun/egr activation. Biochem J 294: 785–791.
  • Ding H,Wu X,Bostrom H,Kim I,Wong N,Tsoi B,O'Rourke M,Koh GY,Soriano P,Betzholtz C,Hart TC,Marazita ML,Field LL,Tam PPL,Nagy A. 2004. A specific requirement for PDGF-C in palate formation and PDGF-Rα signaling. Nat Genet 36: 1111–1116.
  • Hamilton TG,Klinghoffer RA,Corrin PD,Soriano P. 2003. Evolutionary divergence of platelet derived growth factor alpha receptor signaling mechanisms. Mol Cell Biol 23: 4013–4025.
  • Howard CV,Reed MG. 2005. Number estimation. In: Unbiased stereology. New York: BIOS Scientific. p 69–106.
  • Karlsson L,Bondjers C,Betsholtz C. 1999. Roles of PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. Development 126: 2611–2621.
  • Karlsson L,Lindahl P,Heath JK,Betsholtz C. 2000. Abnormal gastrointestinal development in PDGF-A and PDGFR-α deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis. Development 127: 3457–3466.
  • Klinghoffer RA,Hamilton TG,Hoch R,Soriano P. 2002. An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development. Dev Cell 2: 103–113.
  • Lindahl P,Karlsson L,Helstrom M,Gebre-Medhin S,Willetts K,Heath JK,Betsholtz C. 1997. Alveogenesis failure in PDGF-A- deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development. Development 124: 3943–3953.
  • Macfarlane PI,Heaf D. 1990. Changes in airflow obstruction and oxygen saturation in response to exercise and bronchodilators in cystic fibrosis. Pediatr Pulmonol 8: 4–11.
    Direct Link:
  • Maksvytis HJ,Vaccaro C,Brody JS. 1981. Isolation and characterization of the lipid-containing interstitial cell from the developing rat lung. Lab Invest 45: 248–259.
  • Mandeville I,Aubin J,LaBlanc M,Lalancette-Herbert M,Janelle M-F,Trembley GM,Jeannotte L. 2006. Impact of the loss of Hox5a function on lung alveogenesis. Am J Pathol 169: 1312–1327.
  • McGowan SE,Jackson SK,Doro MM,Olson PJ. 1997. Peroxisome proliferators alter lipid acquisition and elastin gene expression in neonatal rat lung fibroblasts. Am J Physiol 273: L1249–L1257.
  • Mergens RTA,Reitsma S,Schiffers PHM,Hilgers RHP,DeMey JGR,Slaaf DW,oude Egbrink MGA,van Zandvoort MAMJ. 2007. Two-photon microscopy of vital murine elastic and muscular arteries. J Vasc Res 44: 87–98.
  • Moreira RK. 2007. Hepatic stellate cells and liver fibrosis. Arch Pathol Lab Med 131: 1728–1734.
  • Oldmixon EH,Carlsson K,Kuhn C,III,Butler JP,Hoppin FG,Jr. 2001. α-Actin: disposition, quantities, and estimated effects on lung recoil and compliance. J Appl Physiol 91: 459–473.
  • Rehan VK,Wang Y,Patel S,Santos J,Torday JS. 2006. Rosiglitazone a peroxisome proliferator activated receptor agonist prevents hyperoxia-induced neonatal rat lung injury in vivo. Pediatr Pulmonol 41: 558–569.
    Direct Link:
  • Scherle W. 1970. A simple method for volumetry of organs in quantitative stereology. Mikroskopie 26: 57–60.
  • Srinivasan S,Strange J,Awonusonu F,Bruce MC. 2002. Insulin-like growth factor I receptor is downregulated after alveolarization in an apoptotic fibroblast subset. Am J Physiol 282: L457–L467.
  • Thibeault DW,Mabry SM,Ekekezie II,Zhang X,Truog WE. 2003. Collagen scaffolding during development and its deformation with chronic lung disease. Pediatrics 111: 766–776.
  • Warburton D,Gauldie J,Belluschi S,Shi W. 2006. Lung development and susceptibility to chronic obstructive pulmonary disease. Proc Am Thorac Soc 3: 668–672.
  • Zhang XQ,Afink GB,Svensson K,Jacobs JJ,Gunther T,Forsberg-Nilsson K,Van Zoelen EJ,Westermark B,Nister M. 1998. Specific expression in mouse mesoderm- and neural crest-derived tissues of a human PDGFRA promoter/lacZ transgene. Mech Dev 70: 167–180.
  • Zhao X-H,Laschinger C,Arora P,Szaszi K,Kapus A,McCulloch CA. 2007. Force activates smooth muscle α-actin promoter activity through the Rho signaling pathway. J Cell Sci 120: 1801–1809.
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