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Imaging & Modeling Techniques
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Assessment of Islet Graft Survival Using a 3.0-Tesla Magnetic Resonance Scanner
Article first published online: 24 OCT 2008
DOI: 10.1002/ar.20770
Copyright © 2008 Wiley-Liss, Inc.
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How to Cite
Jiao, Y., Peng, Z.-H., Xing, T.-H., Qin, J. and Zhong, C.-P. (2008), Assessment of Islet Graft Survival Using a 3.0-Tesla Magnetic Resonance Scanner. Anat Rec, 291: 1684–1692. doi: 10.1002/ar.20770
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Publication History
- Issue published online: 25 NOV 2008
- Article first published online: 24 OCT 2008
- Manuscript Accepted: 28 JUL 2008
- Manuscript Received: 6 MAR 2008
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Keywords:
- islet transplantation;
- graft survival;
- iron labeling;
- 3.0-Tesla magnetic resonance imaging
Abstract
Some studies have recently described a magnetic resonance (MR) method for detection of iron-labeled islets transplanted into the liver. The aim of this work was to assess the survival of islet graft using a clinical 3.0-T scanner. Islets from Lewis rats were cultured in the presence of iron oxide nanoparticles. One thousand iron-labeled islets were transplanted into the portal vein of diabetic rats. Blood glucose levels were measured daily through day 14 post-transplantation. MR imaging of the same section of the liver was performed on 1, 3, 7, 10, and 14 days post-transplantation. The labeled islets were visualized by MR as distinct hypointensive spots distributed in the liver. There was a linear correlation between the relative value of delta R
relaxometry multiplied by the cubic diameter (relative value of the iron volume, Ir) and blood glucose level on 14 days post-transplantation in allograft and isograft (P < 0.05). The relative value of delta R
relaxometry, diameter, and number of hypointensive spots could be calculated to assess the survival of the iron-labeled islet grafts. Assessment of iron-labeled islet grafts using a clinical 3.0-T magnetic resonance scanner represents a useful method that has potential for clinical use. Anat Rec, 2008. © 2008 Wiley-Liss, Inc.