Requirement of TCTG(G/C) Direct Repeats and Overlapping GATA Site for Maintaining the Cardiac-Specific Expression of Cardiac troponin T in Developing and Adult Mice



Transgenic mouse brain shown to the right (top and bottom, dorsal and ventral views, respectively) displays an ectopic expression of LacZ transgene driven by a mutant cardiac troponin T promoter, which contains a 2-bp substitution destroying the critical TCTG(G/C) direct repeats. In contrast, the wild type promoter drives LacZ transgene specifically in the heart (not shown) but not ectopically in the brain shown to the left (top and bottom, dorsal and ventral views, respectively). See Harlan et al., on page 1574, in this issue.