Heparan Sulfates in the Lung: Structure, Diversity, and Role in Pulmonary Emphysema
Article first published online: 19 MAY 2010
Copyright © 2009 Wiley-Liss, Inc.
The Anatomical Record
Volume 293, Issue 6, pages 955–967, June 2010
How to Cite
Smits, N. C., Shworak, N. W., Dekhuijzen, P.N. R. and van Kuppevelt, T. H. (2010), Heparan Sulfates in the Lung: Structure, Diversity, and Role in Pulmonary Emphysema. Anat Rec, 293: 955–967. doi: 10.1002/ar.20895
- Issue published online: 19 MAY 2010
- Article first published online: 19 MAY 2010
- Manuscript Accepted: 5 FEB 2009
- Manuscript Received: 22 DEC 2008
- extracellular matrix;
- heparan sulfates;
There is an emerging interest in the extracellular matrix (ECM) of the lung, especially in the role it plays in development and disease. There is a rapid change from the classical view of the ECM as a supporting structure towards a view of the ECM as a regulatory entity with profound effects on proliferation, migration, and differentiation of pulmonary cells. In the ECM, a variety of molecules is present in a highly organized pattern. Next to the abundant fiber-forming molecules such as collagens and elastin, a large number of less abundant molecules are part of the ECM, including proteoglycans. In this review, we will focus on one class of proteoglycans, the heparan sulfate proteoglycans. We will particularly address the structure, biosynthesis, and function of their saccharide moiety, the heparan sulfates, including their role in development and (patho)physiology. Anat Rec, 293:955–967, 2010. © 2010 Wiley-Liss, Inc.