The Collagen Receptor DDR2 Is Expressed During Early Cardiac Development

Authors

  • Edie C. Goldsmith,

    1. Department of Cell, Biology and Anatomy, University of South Carolina, School of Medicine, Columbia, South Carolina
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  • Xiadong Zhang,

    1. Department of Cell, Biology and Anatomy, University of South Carolina, School of Medicine, Columbia, South Carolina
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  • James Watson,

    1. Department of Cell, Biology and Anatomy, University of South Carolina, School of Medicine, Columbia, South Carolina
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  • Josh Hastings,

    1. Department of Cell, Biology and Anatomy, University of South Carolina, School of Medicine, Columbia, South Carolina
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  • Jay D. Potts

    Corresponding author
    1. Department of Cell, Biology and Anatomy, University of South Carolina, School of Medicine, Columbia, South Carolina
    • Department of Cell, Developmental Biology and Anatomy, University of South Carolina, School of Medicine, Columbia, SC 29209
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Abstract

Discoidin Domain Receptor 2 (DDR2) is a receptor tyrosine kinase which has been shown to regulate cell migration upon binding its ligand, collagen. Expression studies determined that DDR2 mRNA and protein are present in the atrioventricular canal during epithelial-mesenchymal transformation (EMT) and the receptor is expressed in both activated endothelial and migrating mesenchymal cells in vivo. Anat Rec, 2010. © 2009 Wiley-Liss, Inc.

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